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C-reactive protein and high levels of cytokines have been shown to decrease with HBOT.

One study demonstrates that the anti-inflammatory effect from HBOT is probably due to pressure effects and not necessarily increased oxygen tension.

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Efrain Olszewer has pre- and post-angiograms documenting collateral circulation beginning as early as ten to twenty hours after initiating hyperbaric therapy for cerebral vascular disease and peripheral arteriosclerosis at pressures lower than 1.3 ATA It is known that one of the problems children with autism have is decreased blood flow to the brain (cerebral hypoperfusion).Therefore is has been speculated that angioneogenesis is the way that HBOT helps autism However, though angioneogenesis may be one mechanism by which children with autism are helped by HBOT, angioneogenesis may not be the primary mechanism by which HBOT works The amount of cerebral hypoperfusion in autistics compared to controls is about 8%, so a small increase in oxygen delivery may be all that is needed to overcome this deficit and show clinical benefit.• Introduction: Hyperbaric Oxygen Therapy for Neurological and Developmental Disorders • Articles, Books and Recent and New Research Studies on Hyperbaric Oxygen Therapy • Modern Medical Advances: The Use of SPECT Scans and Hyperbaric Oxygen Therapy • Hyperbaric Oxygen Therapy: Treatments for Autism and Other Developmental Disorders • Not All Hyperbaric Chambers Are The Same: Mild Hyperbaric Therapy & Soft Chambers • List of Conditions Accepted by Medicare and Insurance Companies for Reimbursement • Organizations, Associations & Additional Resources for HBOT and Hyperbaric Medicine • Editor's Note: A Few Words on How the HBO Treatment Centers Are Listed On This Site Hyperbaric oxygen therapy is classically defined as the inhalation of 100% oxygen at greater than 1 atmosphere absolute (ATA) in a pressurized chamber.This definition is now popularly defined as the inhalation of varying degrees of oxygen at greater than 1 atmosphere absolute (ATA) in a pressurized chamber. Stoller and myself, and a growing number of other physicians who are now using HBOT routinely in their offices, there remains no doubt that HBOT works and that it works well for children with autism.Therefore, whenever inflammation brings more fluid to a region of the body that is comprised of solid tissue and hollow blood vessels, the first thing to happen is that the hollow blood vessel lumens will be compressed and deliver fewer red cells carrying oxygen to the area.

Once inflammation is reduced the secondary vascular narrowing is improved allowing increasing amounts of red blood cells carrying oxygen to reach the hypoxic areas and SPECT scans will once again "light up" turning from blue to yellow.Children with autism have been shown to have increased oxidative stress and less reduced (active) glutathione HBOT, especially when using pressures less than 2.0 atmospheres, can up-regulate these antioxidant enzymes and afford antioxidant protection against oxidative stress.Mitochondria are the energy producing organelles of the body., not only due to the competing mechanisms of vasodilation and vasoconstriction, but also due to decreasing the inflammation that secondarily constricts blood vessel lumens in a closed spac.Because inflammation is accompanied by swelling, tissue expansion or compression will occur.Recent studies have demonstrated that children with autism frequently have neuro-inflammatory and gastrointestinal inflammatory conditions occurring.