She met her husband, David Arquette, who played her on-screen love interest Dwight "Dewey" Riley, while filming the first Scream film.
Both Cox and Arquette reprised their respective roles from the Scream trilogy in 2011's Scream 4. Her other films include Ace Ventura: Pet Detective with Jim Carrey (1994), The Runner (1999), 3000 Miles to Graceland (2001), and The Shrink Is In (2001).
They hit a rocky patch a couple of years ago but their relationship is clearly happily back on track.
Courteney Cox and fiance Johnny Mc Daid were spotted arm-in-arm as they ran errands in West Hollywood on Tuesday.
It is notably Cox's most successful work since Friends.
The show's third season was to premiere in November 2011, but was moved to February 14, 2012.
In 1995, she was cast in Toad the Wet Sprocket's music video "Good Intentions". At first the most famous cast member of the new show, Cox joined fellow castmates Jennifer Aniston (Rachel Green), Lisa Kudrow (Phoebe Buffay), Matt Le Blanc (Joey Tribbiani), Matthew Perry (Chandler Bing) and David Schwimmer (Ross Geller) for what became her most famous role, lasting for 10 seasons until 2004.
According to the Guinness Book of World Records (2005), Cox (along with her female costars) became the highest-paid TV actress of all time, with her 1 million-per-episode paycheck for the final two seasons of Friends.
The dedication "For Courteney and David, who did get married" – a reference to Monica and Chandler's decision not to marry in the episode – appears during the fade out to the tag scene.
Cox also appeared in the high-profile Hollywood films, Scream (1996), Scream 2 (1997), and Scream 3 (2000), as reporter Gale Weathers.
After the conclusion of Friends, Cox was producer Marc Cherry's first choice to be offered a starring role as Susan Mayer on Desperate Housewives, but Cox was unavailable due to her pregnancy and the role later went to Teri Hatcher.
A few years later, Cox signed a deal with ABC Studios (formerly Touchstone Television) to star in her own series.
A Friends reunion film was rumored to be in production following the success of Sex and the City (2008), but this has been denied by Warner Bros. Cox starred as Lucy Spiller, a cynical tabloid editor, in Dirt (2007), a television drama for FX.