The MQM charter was paramount in expressing many of the "long-standing grievances" of Sindhi nationalists, Altaf Hussain revealed that while he was admitted in Abbasi Shaheed Hospital in 1988, Late Hameed Gul (ISI chief at the time) sent briefcase full of money through Brigadier(R) Imtiaz and tried to bribe him in joining Pakistan military establishment led IJI coalition which was against PPP but he rejected the offer.
On 31 October 1986, Altaf Hussain gave his first public address in Hyderabad at the site of the historic Pacco Qillo, where he was greeted by throngs of crowds.
After his address, his message was well received by the Urdu-speaking people of Hyderabad and Hussain was able to fill the void left by the deaths of Muhajir leaders.
He later enrolled in the Government Boys Secondary School to complete his matriculation in 1969.
For the first year of his intermediate education in pre-medical sciences, he attended the National College Karachi.
In 1979, he graduated from the University of Karachi with a Bachelor of Pharmacy.
After graduating from the university, Hussain began his career as a trainee at the Seventh-day Adventist Hospital in Karachi while simultaneously working for a multinational pharmaceutical company.His arrest enraged his supporters who launched public movements for his release.The charges against Hussain and his companions were later dropped and they were released from the Central Prison Karachi on 24 February 1987.Hussain's siblings include four sisters and six brothers.Following the independence of Pakistan in 1947, a wide-scale migration of Muslims ensued where they migrated from the various Muslim-majority states in India to the newly established Dominion of Pakistan.The political strife of the APMSO bifurcated into the issue of stranded Pakistanis in Bangladesh an on 14 August 1979, Hussain participated in a demonstration at the Mazar-e-Quaid for the safe return of stranded Pakistanis, also called the Biharis.